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Week 1

Buffalo Bills at LA 
Thursday, September 8th, 2022
8:20pm Kickoff

Result: Bills 31 - LA 10
Record: 1-0

 

Week 2

Buffalo Bills vs. Tennessee
Monday, September 19th, 2022
7:15pm Kickoff

Result: Bills 41 - Tennessee 7
Record: 2-0

Week 3

Buffalo Bills at Miami
Sunday, September 25th, 2022
1:00pm Kickoff

Result: Bills 19 - Miami 21
Record: 2-1

 

Week 4

Buffalo Bills at Baltimore
Sunday, October 2nd, 2022
1:00pm Kickoff

Week 5

Buffalo Bills vs. Pittsburgh
Sunday, October 9th, 2022
1:00pm Kickoff

Week 6

Buffalo Bills at Kansas City
Sunday, October 16th, 2022
4:25pm Kickoff

Week 7

BYE Week

Week 8

Buffalo Bills vs. Green Bay
Sunday, October 30th, 2022
8:20pm Kickoff

Week 9

Buffalo Bills at NY
Sunday, November 6th, 2022
1:00pm Kickoff

Week 10

Buffalo Bills vs. Minnesota
Sunday, November 13th, 2022
1:00pm Kickoff

Week 11

Buffalo Bills vs. Cleveland
Sunday, November 11th, 2022
1:00pm Kickoff

Week 12

Buffalo Bills at Detroit
Thursday, November 24th, 2022
12:30pm Kickoff

Week 13

Buffalo Bills at New England
Thursday, December 1st, 2022
8:15pm Kickoff

Week 14

Buffalo Bills vs. NY
Sunday, December 11th, 2022
1:00pm Kickoff

Week 15

Buffalo Bills vs. Miami
TBD

Week 16

Buffalo Bills at Chicago
Saturday, December 24th, 2022
1:00pm Kickoff

Week 17

Buffalo Bills at Cincinnati 
Monday, January 2nd, 2022
8:30pm Kickoff

Week 18

Buffalo Bills vs. New England
TBD

 

Key:
Blue = Home
Red = Away

Availability